Presentation title: What triggers and promotes celiac disease and can we prevent it? Lessons learnt from observational birth cohort studies.
The aim of Daniel´s research is to contribute to better understanding of how early life events lead to progression of lifelong autoimmunity. His field of research has focused on identifying environmental as well as genetic risk factors associated with celiac disease in children with emphasis on early life exposures.
His research from international birth cohort studies on type 1 diabetes and celiac disease has revealed several important findings related to diet, infections, perinatal factors and how they interact on the risk of developing autoimmune disease like type 1 diabetes and celiac disease during early childhood.
Daniel Agardh´s talk will focus on the observations made from The Environmental Determinants of the Diabetes in the Young (TEDDY) study; the world´s largest ongoing multinational prospective observational study on type 1 diabetes and celiac disease. Based on the current knowledge of identified triggers and promoters in celiac disease, he will also discuss how the experiences from TEDDY and similar screening studies have been used for starting up new prevention and intervention studies involving infants at genetic risk.